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Expanding our understanding of the role polyprotein conformation plays in the coronavirus life cycle

Show simple item record Gildenhuys, Samantha 2020-06-03T14:42:44Z 2020-06-03T14:42:44Z 2020
dc.identifier.citation Biochemical Journal (2020) 477 1479–1482 en
dc.description Connected Content This is a commentary on: Processing of the SARS-CoV pp1a/ab nsp7–10 region
dc.description.abstract Coronavirus are the causative agents in many globally concerning respiratory disease outbreaks such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and coronavirus disease-2019 (COVID-19). It is therefore important that we improve our understanding of how the molecular components of the virus facilitate the viral life cycle. These details will allow for the design of effective interventions. Krichel and coauthors in their article in the Biochemical Journal provide molecular details of how the viral polyprotein (nsp7–10) produced from the positive single stranded RNA genome, is cleaved to form proteins that are part of the replication/transcription complex. The authors highlight the impact the polyprotein conformation has on the cleavage efficiency of the main protease (Mpro) and hence the order of release of non-structural proteins 7–10 (nsp7–10) of the SARS-CoV. Cleavage order is important in controlling viral processes and seems to have relevance in terms of the protein–protein complexes formed. The authors made use of mass spectrometry to advance our understanding of the mechanism by which coronaviruses control nsp 7, 8, 9 and 10 production in the virus life cycle. en
dc.language.iso en en
dc.publisher Portland Press en
dc.subject Covid-19
dc.subject Coronavirus,
dc.subject nsp7–10
dc.subject polyprotein
dc.subject 1a/ab
dc.subject polyprotein conformation
dc.subject posttranslational control
dc.subject SARS-CoV
dc.title Expanding our understanding of the role polyprotein conformation plays in the coronavirus life cycle en
dc.type Article en
dc.description.department Life and Consumer Sciences

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