Molecular characterization of Aeromonas hydrophila and antimicrobial activities of selected medicinal plants against pathogenic isolates from water and stool samples in the era of HIV/AIDS in Limpopo Province, South Africa
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Authors
Ramalivhana, Naledzani Jeoffry
Issue Date
2010-05
Type
Thesis
Language
en
Keywords
Aeromonas hydrophila , Pathogenic isolates , Antimicrobial activities , HIV/AIDS
Alternative Title
Abstract
Aeromonas hydrophila is distributed widely in nature and is responsible for an array of
human infections. Several studies on the isolation and characterisation of the organism
abound. Although there are reports on the antibiotic resistance profiles of the organism,
these reports have not been updated in Limpopo province, South Africa despite the
established fact that antibiograms vary with time and geographical area. Antibiotic
resistance and pathogenesis of an organism are dependent on a host of factors such as the
production of extended spectrum beta-lactamases and the genetic profiles such as the genes
coding for resistance and possession of integrons and how these characteristics overach
with the phylogenetic inter-relatedness of isolates from different sources. In spite of the
aforementioned concerns on the efficacy of antibiotics due to the acquisition or endowment
of microorganisms with intrinsic and extrinsic factors , which enhances resistance to
antibiotics , medicinal plants are reportedly offering promise as alternative sources of
efficacious management of infections. Medicinal plants are employed by traditional healers
in the management of infections in developing countries especially in Africa. However, the
antimicrobial activities of medicinal plants against Aeromonas hydrophila have received only
a cursory attention.
In an endeavour to undertake a comprehensive study on the isolation, characterisation,
antibiograms, activities of medicinal plants as well as the genetic profiles, including
phylogenetics relatedness of Aeromonas isolates from different sources, stool and water
samples were collected over a two year period from designated places in Limpopo Province
and analysed using standard techniques applicable to the constituent research activity. The
research findings are presented in six chapters as presented hereunder.
The first chapter focussed on the literature review of the organism and reflects areas such as
the morphology, laboratory diagnosis, clinical manifestations, pathogenesis, antimicrobial
susceptibility profiles, antibacterial activities of medicinal plants as well as the genetic
aspects of Aeromonas hydrophila.
Description
Citation
Ramalivhana, Naledzani Jeoffry (2010) Molecular characterization of Aeromonas hydrophila and antimicrobial activities of selected medicinal plants against pathogenic isolates from water and stool samples in the era of HIV/AIDS in Limpopo Province, South Africa, University of South Africa, Pretoria, <http://hdl.handle.net/10500/4309>