The utility of thrombo-elastography in the monitoring of aspirin therapy
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Authors
Mayne E.
Jacobson B.
Louw S.
Bernstein P.
Mayne A.
Issue Date
2007
Type
Article
Language
en
Keywords
acetylsalicylic acid; adenosine diphosphate; adrenalin; arachidonic acid; adult; analyzer; article; blood clotting; blood sampling; controlled study; drug dose regimen; drug response; human; human experiment; intermethod comparison; low drug dose; normal human; platelet aggregometry; thrombocyte aggregation; thromboelastography; treatment duration; volunteer; Analysis of Variance; Aspirin; Blood Coagulation; Dose-Response Relationship, Drug; Humans; Middle Aged; Monitoring, Physiologic; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Reproducibility of Results; Thrombelastography; Thrombosis
Alternative Title
Abstract
To assess the utility of the thrombo-elastogram in monitoring of aspirin therapy 25 healthy volunteers were selected and given low-dose aspirin therapy. Thrombo-elastography and platelet aggregometry were conducted at baseline and 1 week later. After 1 week of aspirin therapy, thrombo-elastogram data failed to demonstrate a significant change in the clotting profile, Platelet aggregometry identified significant changes in the clotting profile in response to stimulation with arachidonic acid, adrenaline and ADP. We conclude that thrombo-elastography may not have utility in monitoring of response to aspirin.
Description
Citation
South African Medical Journal
97
12 I
97
12 I
Publisher
License
Journal
Volume
Issue
PubMed ID
DOI
ISSN
2569574