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Molecular Characterization of Rotavirus Strains Circulating in Oman in 2005
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| dc.contributor.author | Al Baqlani, Said
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| dc.contributor.author | Dewar, John
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| dc.contributor.author | Pearson, Lindsey
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| dc.contributor.author | Mothokoa, Charles
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| dc.contributor.author | Rupa, Varghese
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| dc.contributor.author | Al Awaidy, Salah
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| dc.contributor.author | Peenze, Ina
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| dc.contributor.author | Al Busaidy, Suleiman
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| dc.contributor.author | Steele, Duncan A.
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| dc.contributor.author | Al Lawati, Zainab
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| dc.date.accessioned | 2011-02-01T10:51:14Z | |
| dc.date.available | 2011-02-01T10:51:14Z | |
| dc.date.issued | 2010-09 | |
| dc.identifier.citation | DOI: 10.1086/653582 | en |
| dc.identifier.issn | 0022-1899 (Online) | |
| dc.identifier.uri | http://hdl.handle.net/10500/3967 | |
| dc.description.abstract | Limited genotyping data are available for rotavirus strains in the Middle East. In this study, we investigated the molecular epidemiology of human rotavirus strains circulating in the Sultanate of Oman during 2005. Rotavirus was detected in 178 (57.4%) of 310 of the diarrheal stools of young children under 5 years admitted to hospitals and outpatients clinics. Polyacrylamide gel electrophoresis demonstrated the cocirculation of 8 strains, although 2 strains predominated across the Sultanate. Genotyping revealed the presence of human rotavirus strains of types G1P[8], G2P[4], and G3P[8]. Several strains exhibited unusual combinations of G and P genotypes and RNA electropherotypes, indicating the likelihood of natural reassortment events occurring with a high frequency. In addition, the unusual P[10] genotype was identified among the rotavirus strains, in combination with the G1 type. | en |
| dc.description.sponsorship | Financial support: World Health Organization (grant V27/181/113), Rotavirus Vaccine Program (grant GAV.1142-01-07211-SPS), Norwegian Council for Higher Education (grant PRO 48/2002), Ministry of Health, Oman, and Medical Research Council of South Africa. Presented in part: Virology in Africa Conference, Cape Town, South Africa, November 2005; Second International Congress on Infectious Tropical Diseases, Muscat, Oman, November 2006. Supplement sponsorship: This article is part of a supplement entitled “Rotavirus Infection In Africa: Epidemiology, Burden of Disease, and Strain Diversity,” which was prepared as a project of the Rotavirus Vaccine Program, a partnership among PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance. Reprint requests and correspondence: Dr. Duncan Steele, 1455 Leary Way NW | en |
| dc.language.iso | en | en |
| dc.publisher | The University of Chicago Press | en |
| dc.subject | Rotavirus strains | en |
| dc.subject | Human rotavirus strains | en |
| dc.subject | Rotavirus | en |
| dc.subject | Sultanate of Oman | en |
| dc.subject | Middle East | en |
| dc.subject | Polyacrylamide gel electrophoresis | en |
| dc.title | Molecular Characterization of Rotavirus Strains Circulating in Oman in 2005 | en |
| dc.type | Article | en |
