The utility of thrombo-elastography in the monitoring of aspirin therapy

Mayne E.; Jacobson B.; Louw S.; Bernstein P.; Mayne A.

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dc.contributor.author	Mayne E.	en
dc.contributor.author	Jacobson B.	en
dc.contributor.author	Louw S.	en
dc.contributor.author	Bernstein P.	en
dc.contributor.author	Mayne A.	en
dc.date.accessioned	2012-11-01T16:31:27Z
dc.date.available	2012-11-01T16:31:27Z
dc.date.issued	2007	en
dc.identifier.citation	South African Medical Journal	en
dc.identifier.citation	97	en
dc.identifier.citation	12 I	en
dc.identifier.issn	2569574	en
dc.identifier.uri	http://hdl.handle.net/10500/7245
dc.description.abstract	To assess the utility of the thrombo-elastogram in monitoring of aspirin therapy 25 healthy volunteers were selected and given low-dose aspirin therapy. Thrombo-elastography and platelet aggregometry were conducted at baseline and 1 week later. After 1 week of aspirin therapy, thrombo-elastogram data failed to demonstrate a significant change in the clotting profile, Platelet aggregometry identified significant changes in the clotting profile in response to stimulation with arachidonic acid, adrenaline and ADP. We conclude that thrombo-elastography may not have utility in monitoring of response to aspirin.	en
dc.language.iso	en	en
dc.subject	acetylsalicylic acid; adenosine diphosphate; adrenalin; arachidonic acid; adult; analyzer; article; blood clotting; blood sampling; controlled study; drug dose regimen; drug response; human; human experiment; intermethod comparison; low drug dose; normal human; platelet aggregometry; thrombocyte aggregation; thromboelastography; treatment duration; volunteer; Analysis of Variance; Aspirin; Blood Coagulation; Dose-Response Relationship, Drug; Humans; Middle Aged; Monitoring, Physiologic; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Reproducibility of Results; Thrombelastography; Thrombosis	en
dc.title	The utility of thrombo-elastography in the monitoring of aspirin therapy	en
dc.type	Article	en