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Group B Streptococcus colonization during pregnancy and maternal-fetal transmission in Zimbabwe

Show simple item record Mavenyengwa R.T. en Afset J.E. en Schei B. en Berg S. en Caspersen T. en Bergseng H. en Moyo S.R. en 2012-11-01T16:31:21Z 2012-11-01T16:31:21Z 2010 en
dc.identifier.citation Acta Obstetricia et Gynecologica Scandinavica en
dc.identifier.citation 89 en
dc.identifier.citation 2 en
dc.identifier.issn 16349 en
dc.identifier.other 10.3109/00016340903398029 en
dc.description.abstract Objective. To explore risk factors for group B Streptococcus (GBS) colonization during pregnancy and at delivery, estimate the predictive value of early GBS colonization for colonization at delivery and in the newborn, and explore the relationship to adverse perinatal factors. Design and setting. Cohort study of pregnant women from three communities in Zimbabwe. Methods. Information collected by questionnaire at inclusion and from delivery records. Vaginal and rectal swabs collected for GBS culture at 20 and 26 weeks gestation, at delivery and from the newborn infant. Main outcome measures. GBS colonization in pregnancy, colonization of mother and newborn, and perinatal factors. Results. GBS culture results were obtained at one or more occasion for 780 (75.2%) of 1,037 women recruited. Altogether, 470/780 women (60.3%) tested positive for GBS, with colonization rates at 20, 26 weeks and delivery of 47%, 24.2% and 21%, respectively. Positive GBS culture at 20 and 26 weeks gestation had a low positive predictive value on colonization at delivery and in the newborn. Women living in rural areas were significantly more often colonized than those who lived in urban areas (p < 0.001). Other socio-economic, demographic and obstetric factors were not statistically associated with GBS colonization. GBS transmission was not statistically significantly associated with adverse perinatal outcomes. Conclusions. GBS colonization was common among pregnant women in Zimbabwe. Dwelling in a rural area was significantly associated with GBS colonization while other risk factors were not. Early GBS colonization had a low predictive value for colonization at delivery and colonization was not associated with adverse perinatal outcome. © 2010 Informa UK Ltd. en
dc.language.iso en en
dc.subject Epidemiology; GBS colonization; Risk-factors; Transmission rate adult; article; bacterial colonization; bacterium culture; delivery; female; gestational age; group B streptococcal infection; human; infant; major clinical study; newborn; nonhuman; pregnancy; priority journal; rectum; risk factor; rural area; social status; Streptococcus agalactiae; urban area; vagina; vertical transmission; Zimbabwe; Birth Weight; Cohort Studies; Delivery, Obstetric; Female; Gestational Age; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Meconium; Predictive Value of Tests; Pregnancy; Pregnancy Complications, Infectious; Risk Factors; Rural Population; Streptococcal Infections; Streptococcus agalactiae; Urban Population; Zimbabwe en
dc.title Group B Streptococcus colonization during pregnancy and maternal-fetal transmission in Zimbabwe en
dc.type Article en

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