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A phytochemical and biological investigation of Sutherlandia Frutescens

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dc.contributor.advisor Meyer, M. S.
dc.contributor.advisor Steenkamp, P. A.
dc.contributor.advisor Dewar, J. B.
dc.contributor.author Faleschini, Maria Teresa
dc.date.accessioned 2012-06-11T09:36:48Z
dc.date.available 2012-06-11T09:36:48Z
dc.date.issued 2011-11
dc.date.submitted 2012-06
dc.identifier.uri http://hdl.handle.net/10500/5787
dc.description.abstract Since ancient times, indigenous plants have been used by traditional healers for treating various ailments. Sutherlandia frutescens is one of the most commonly used medicinal plants of southern Africa. This widely distributed plant has been traditionally used to treat cancer and HIV patients; however scientific validation is still in high demand. This research aimed to phytochemically characterise the various extracts prepared and to determine if any chemotypes were present. Subsequent biological characterisation was carried out to preliminary ascertain whether this medicinal plant could have anti-cancer and/or immunemodulating properties and which compounds might be responsible for these actions. Various traditional and organic extracts were prepared. Extracts, fractions and compounds generated were analysed and chemical profiles obtained. Column chromatographic techniques were used to isolate and purify compounds and structure elucidation was carried out using various analytical techniques. Sulforhodamine B and cytometric bead array assays were performed to determine the biological activities of samples generated. en
dc.format.extent 1 online resource (xxi, 147 leaves.)
dc.language.iso en en
dc.subject Anti-cancer en
dc.subject Immune-modulating en
dc.subject Sulforhodamine B en
dc.subject Nuclear Magnetic Resonance en
dc.subject Chemotypes en
dc.subject Phytochemistry en
dc.subject Sutherlandia frutescens
dc.subject Tradisional uses
dc.subject HIV
dc.subject Cytometric bead arrays
dc.subject.ddc 615.3210968
dc.subject.lcsh Phytochemicals -- Research -- Africa, Southern
dc.subject.lcsh Biology -- Research -- Africa, Southern
dc.subject.lcsh Legumes -- Research -- Africa, Southern
dc.title A phytochemical and biological investigation of Sutherlandia Frutescens en
dc.type Dissertation en
dc.description.department Life and Consumer Sciences
dc.description.degree (M. Sc. (Life Sciences)


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