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Diversity of Rotavirus VP7 and VP4 Genotypes in Northwestern Nigeria

Show simple item record Aminu, M. Ahmad, A.A. Steele, A.D. Page, N.A. Dewar, J. Umoh, J.U. 2011-02-01T10:47:42Z 2011-02-01T10:47:42Z 2010-09
dc.identifier.citation DOI: 10.1086/653570 en
dc.identifier.issn 0022-1899 (Online)
dc.description.abstract Background: Nigeria has recently been ranked third among the 10 countries with the greatest number of rotavirus disease–associated deaths per year. Estimates attribute up to 33,000 deaths annually to rotavirus disease in Nigerian children under 5 years old. Although the introduction of the new oral, live attenuated rotavirus vaccines may not occur for another 4–6 years in developing countries, background data on burden of disease, cost of rotavirus disease, and characterization of circulating strains is required to hasten this introduction to children who would clearly benefit from the intervention. Methods: Between July 2002 and July 2004, fecal specimens were collected from 869 infants and young children under 5 years of age presenting with diarrhea in Kaduna, Kebbi, Sokoto, and Zamfara states in northwestern Nigeria. In addition, 194 control specimens were also collected from children matched for age. Specimens were screened for the presence of rotavirus antigens. Rotavirus-positive specimens were further analyzed to determine electropherotype,subgroup specificity, and G and P genotypes. Results: Rotavirus was detected in 18% of children with diarrhea and 7.2% of the age-matched case control subjects. The highest rotavirus burden was detected in children aged undre 6 months. The majority of the rotaviruspositive specimens revealed viruses of long electropherotypes, subgroup II specificity, and G1P[8] genotypes. Furthermore, more than a quarter of specimens (37%) displayed mixed G and P genotypes, and almost a third could not be genotyped. Conclusions. The high numbers of mixed rotavirus infections highlight the multitude of enteric pathogens to which children in African countries are exposed. Data on circulating rotavirus strains serve to inform African government officials to the serious health threat posed by rotavirus in their respective countries and to document the diversity of strains before vaccine introduction. en
dc.description.sponsorship Financial support: UNESCO-L’ORE´AL Fellowship for Women in Life Sciences, World Health Organization, and Medical Research Council of South Africa. Supplement sponsorship: This article is part of a supplement entitled “Rotavirus Infection In Africa: Epidemiology, Burden of Disease, and Strain Diversity,” which was prepared as a project of the Rotavirus Vaccine Program, a partnership among PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance. en
dc.language.iso en en
dc.publisher The University of Chicago Press en
dc.subject Rotavirus disease en
dc.subject Attenuated rotavirus vaccines en
dc.subject Rotavirus antigens en
dc.subject G1P[8] genotypes en
dc.subject Nigerian children en
dc.subject Live attenuated rotavirus vaccines en
dc.subject Enteric pathogens en
dc.title Diversity of Rotavirus VP7 and VP4 Genotypes in Northwestern Nigeria en
dc.type Article en

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