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Genexpert data for Rifampicin resistance in Swaziland - a retrospective analysis from 2012-2016

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dc.contributor.author Zanamwe, Tafara
dc.date.accessioned 2020-02-12T13:06:35Z
dc.date.available 2020-02-12T13:06:35Z
dc.date.issued 2019-07
dc.identifier.uri http://hdl.handle.net/10500/26263
dc.description.abstract Surveillance of anti-TB drug resistance is key for sustained TB control. GeneXpert may provide a new avenue at least for Rifampicin resistance surveillance. This study used GeneXpert data to determine epidemiological prevalence of rifampicin resistance in Swaziland from 2012–2016. Nine laboratories in Swaziland were purposively selected and from them 50% of GeneXpert records were included in the study. Data was analysed using SAS studio version 9.04. Of the 5418 GeneXpert records included, 50.8% were from males. The prevalence of rifampicin resistance was 10.5%, 10.8%, 11.3, 11,3 and 11,8 for 2012, 2013, 2014, 2015 and 2016 respectively. Further, probe E was the most common locus of mutation conferring rifampicin resistance accounting for 62.2% of all resistance. This study showed that routine data from GeneXpert can be used for epidemiological surveillance of rifampicin resistance and can be used to develop a simple continuous system of rifampicin resistance surveillance. en
dc.language.iso en en
dc.subject Descriptive correlational en
dc.subject GeneXpert en
dc.subject New TB patients en
dc.subject Previously treated TB patients en
dc.subject Rifampicin resistance en
dc.subject Anti-tuberculosis drug resistance surveillance en
dc.subject Molecular probes en
dc.subject Xpert MTB rif en
dc.subject rpoB gene en
dc.subject Rifampicin resistance patterns en
dc.subject Rifampicin resistance proportion en
dc.title Genexpert data for Rifampicin resistance in Swaziland - a retrospective analysis from 2012-2016 en
dc.type Dissertation en
dc.description.department Health Studies en


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  • Unisa ETD [9274]
    Electronic versions of theses and dissertations submitted to Unisa since 2003

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