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Investigating the production of secondary metabolites effective in lowering blood glucose levels in Euclea Undulata Thunb. Var Myrtina (Ebenaceae)

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dc.contributor.advisor Deutschländer, M.
dc.contributor.advisor Prinsloo, G.
dc.contributor.author Botha, Lynette Elizabeth
dc.date.accessioned 2017-01-17T09:22:52Z
dc.date.available 2017-01-17T09:22:52Z
dc.date.issued 2016-03
dc.identifier.citation Botha, Lynette Elizabeth (2016) Investigating the production of secondary metabolites effective in lowering blood glucose levels in Euclea Undulata Thunb. Var Myrtina (Ebenaceae), University of South Africa, Pretoria, <http://hdl.handle.net/10500/21927> en
dc.identifier.uri http://hdl.handle.net/10500/21927
dc.description.abstract Euclea undulata Thunb. var myrtina is a widely distributed shrub in South Africa. The roots are used by traditional healers for the treatment of diabetes. Research indicates that roots contain epicatechin, lupeol as well α-amyrin-3O-β-(5-hydroxy) ferulic acid. It was found that α-amyrin-3O-β-(5-hydroxy) ferulic acid inhibits α-glucosidase while epicatechin lowers glucose levels in the blood. Existing literature also indicates the presence of the naphthoquinone 7-methyl-juglone in the roots, although it was not detected in all cases. Due to its cytotoxic nature, 7-methyl-juglone poses a potential threat when E. undulata is used as medicinal treatment. In order to assist the effective and safe use of this plant as a treatment for diabetes, this project aims to determine whether the presence of these metabolites is seasonal. It further aims to contribute to more sustainable harvesting methods by investigating stems and leaves in addition to the roots for the presence of these metabolites. en
dc.format.extent 1 online resource (xviii, 116 leaves) : color illustrations, color maps en
dc.language.iso en en
dc.subject Euclea undulata en
dc.subject Epicatechin en
dc.subject Lupeol en
dc.subject α-amyrin-3O-β-(5-hydroxy) ferulic acid en
dc.subject 7-methyl-juglone en
dc.subject Diabetes mellitus en
dc.subject Secondary metabolites en
dc.subject Statistical analysis en
dc.subject Chemical analysis en
dc.subject Rainy season en
dc.subject Dry season en
dc.subject Roots en
dc.subject Stems en
dc.subject Leaves en
dc.subject.ddc 614.46206
dc.subject.lcsh Diabetes -- Alternative treatment en
dc.subject.lcsh Traditional medicine -- South Africa en
dc.subject.lcsh Phytochemicals -- Analysis en
dc.title Investigating the production of secondary metabolites effective in lowering blood glucose levels in Euclea Undulata Thunb. Var Myrtina (Ebenaceae) en
dc.type Dissertation en
dc.description.department Environmental Sciences en
dc.description.degree M. Sc. (Environmental Science) en


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