Antioxidative, analgesic and anti-inflammatory activities of Acokanthera oppositifolia, Plantago lanceolata, Conyza canadensis, and Artemisia vulgaris

Ondua, Moise

dc.contributor.advisor	Lebelo, S. L.
dc.contributor.advisor	Shai, L. J.
dc.contributor.author	Ondua, Moise
dc.date.accessioned	2015-10-05T12:36:49Z
dc.date.available	2015-10-05T12:36:49Z
dc.date.issued	2015-02
dc.identifier.citation	Ondua, Moise (2015) Antioxidative, analgesic and anti-inflammatory activities of Acokanthera oppositifolia, Plantago lanceolata, Conyza canadensis, and Artemisia vulgaris, University of South Africa, Pretoria, <http://hdl.handle.net/10500/19169>	en
dc.identifier.uri	http://hdl.handle.net/10500/19169
dc.description.abstract	The anti-inflammatory properties of four medicinal plants were investigated. These plant extracts were subjected to screening for their possible effects as antioxidative, analgesic, and anti-inflammatory agents. In the antioxidant activity, the Plantago lancelota extracts resulted in an IC50 value of 0.4 mg/mL compared to the positive control quecertin with IC50 0.04 mg/mL Plantago lanceolata inhibited COX-2 activity with IC50 values of 0.41 mg/mL. However, the COX-1 inhibition indicated an IC50 of 68.99 mg/mL. The lipoxygenase assay indicated that Plantago lanceolata was the most active plant species with an IC50 value of 4.86 mg/mL compared to the positive control (quecertin) with an IC50<2mg/mL. The nitric oxide assay of the plant extracts indicates a dose-dependent activity of our plant extracts. Likewise the cell viability result indicated a good activity at dose 100 mg/mL.	en
dc.format.extent	1 online resource (xv, 104 leaves), illustrations (some color)
dc.language.iso	en	en
dc.subject	Plantago lanceolata	en
dc.subject	Conyza canadensis	en
dc.subject	Acokantera oppositifolia	en
dc.subject	Artemisia vulgaris	en
dc.subject	Antioxidant	en
dc.subject	Anti-inflammatory	en
dc.subject	Nitric oxide	en
dc.subject	Cell viability	en
dc.subject	Raw 264.7 macrophages	en
dc.subject	Lypoxygenase	en
dc.subject	Cyclooxygenase-1	en
dc.subject	Cyclooxygenase-2	en
dc.subject.ddc	615.321
dc.subject.lcsh	Antioxidants
dc.subject.lcsh	Analgesics
dc.subject.lcsh	Anti-inflammatory agents\|
dc.subject.lcsh	Medicinal plants
dc.subject.lcsh	Medicinal plants -- South Africa -- Research
dc.title	Antioxidative, analgesic and anti-inflammatory activities of Acokanthera oppositifolia, Plantago lanceolata, Conyza canadensis, and Artemisia vulgaris	en
dc.type	Dissertation	en
dc.description.department	Life and Consumer Sciences	en
dc.description.degree	M. Sc. (Life Sciences)