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The impact of Isoniazid Preventive Therapy (IPT) on tuberculosis incidence among HIV infected patients in Addis Ababa, Ethiopia

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dc.contributor.advisor Negussie, T.
dc.contributor.author Sade, Anteneh Habtenarian
dc.contributor.author Anteneh Habtemariam Sade
dc.date.accessioned 2013-10-24T07:02:14Z
dc.date.available 2013-10-24T07:02:14Z
dc.date.issued 2013-10-24
dc.identifier.citation Anteneh Habtemariam Sade (2013) The impact of Isoniazid Preventive Therapy (IPT) on tuberculosis incidence among HIV infected patients in Addis Ababa, Ethiopia, University of South Africa, Pretoria, <http://hdl.handle.net/10500/11917> en
dc.identifier.uri http://hdl.handle.net/10500/11917
dc.description.abstract Background: IPT is an effective, safe and feasible disease prevention scheme that should be administered for all PLHIV living in areas with high latent TB prevalence. Objective: To assess the impact of isoniazid in the incidence of tuberculosis among HIV infected individuals in Addis Ababa. Methods: A case control study design was undertaken among 489 HIV and TB infected patients in Addis Ababa from January 2008 to December 2010. Results: Tuberculosis incidence rate among those who developed TB after completing 6-9 month isoniazid preventative therapy was17.14 PYO compared to 10.28 PYO among those who were not. Isonizide reduced the chance of developing tuberculosis among HIV infected patients (OR= 0.072; 95% CI 0.044, 0.12). Age (AOR= 0.14; 95% CI 0.03, 0.97) and sex (AOR= 1.86; 95% CI 1.02, 2.23) of the patient, CD4 count at HIV diagnosis (AOR= 0.21; 95% CI 0.13, 0.31), clinical stage of HIV illness (AOR= 1.22; 95% CI 1.09, 1.84) and past tuberculosis history (AOR = 1.97; 95% CI 1.24, 3.67) were major factors associated with tuberculosis incidence. Conclusions: INH prophylaxis was associated with lower incidence of tuberculosis among PLHIV. en
dc.format.extent 1 online resource (vii, 71 leaves)
dc.language.iso en en
dc.subject IPT en
dc.subject Tuberculosis en
dc.subject Incidence en
dc.subject HIV en
dc.subject Addis Ababa en
dc.subject.ddc 616.979209633
dc.subject.lcsh Isoniazd -- Tuberculosis -- Ethiopia -- Addis Ababa
dc.subject.lcsh Highly active antiretroviral therapy -- Tuberculosis -- Ethiopia -- Addis Ababa
dc.subject.lcsh HIV-positive persons -- Tuberculosis -- Ethiopia -- Addis Ababa
dc.subject.lcsh Tuberculosis -- Ethiopia -- Addis Ababa
dc.subject.lcsh Therapeutics -- Tuberculosis -- Ethiopia -- Addis Ababa
dc.title The impact of Isoniazid Preventive Therapy (IPT) on tuberculosis incidence among HIV infected patients in Addis Ababa, Ethiopia en
dc.type Dissertation en
dc.description.department Health Studies en
dc.description.degree M. Public Health


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